I better reinstall my OS/Apps from my 8x Stripe SSD array :-) sorry couldn't help my self
OS and APPS can always be reinstalled on either single, stripe or mirror, but its your data that you really have to worry about, though all my Arrays on my workstation is RAID-0 Stripe, i back up to an external unit Synology 1812+ 8x 3TB RAID-6/Synology RAID-6 + this will also be backed up to individual drives. I start by copying my RAW files first to the Synology, and then to the work station, I then work on the files on the work stations with all WIP gets copied to the Synology.
but to answer the OP then you will find that because you are making large pano's you will almost always hit your scratch disk... for your setup there isn't any BEST setup, they will all be compromises.
BOOT disk will be your fastest SSD, your scratch disk should be your other SSD and your data on your HDD's mirror them if you do not have a backup plan
Hope this helps
PS: despite my 20+ SSD's its across 3 raid controllers its still not optimal, but it does help when you push 1-2+GB/s :-)
an OS I would never place on a RAID 0. one disc failing and you've a lot of overtime.
so maybe a RAID 1 for the OS.
PS: I have a Dell XPS and it comes by default with a RAID 0. I've noe clue what I did finally to succeed, I only remember that it took some time inclusive fresh install of win7 to succeed. ah... my XPS 8100 is limited to 16GB, which one doess allow 24GB?